Study: Long-Term Marijuana Use Changes Brain’s Reward Circuit

Medical Xpress reports:

Chronic marijuana use disrupts the brain’s natural reward processes, according to researchers at the Center for BrainHealth at The University of Texas at Dallas.

1-studylongterIn a paper published in Human Brain Mapping, researchers demonstrated for the first time with functional magnetic resonance imaging that long-term  users had more  activity in the mesocorticolimbic-reward system when presented with cannabis cues than with natural reward cues.

“This study shows that marijuana disrupts the natural reward circuitry of the brain, making marijuana highly salient to those who use it heavily. In essence, these brain alterations could be a marker of transition from recreational marijuana use to problematic use,” said Dr. Francesca Filbey, director of Cognitive Neuroscience Research in Addictive Disorders at the Center for BrainHealth and associate professor in the School of Behavioral and Brain Sciences.

Researchers studied 59 adult marijuana users and 70 nonusers, accounting for potential biases such as traumatic brain injury and other drug use. Study participants rated their urge to use marijuana after looking at various visual cannabis cues, such as a pipe, bong, joint or blunt, and self-selected images of preferred fruit, such as a banana, an apple, grapes or an orange.

Researchers also collected self-reports from study participants to measure problems associated with marijuana use. On average, marijuana participants had used the drug for 12 years.

When presented with marijuana cues compared to fruit, marijuana users showed enhanced response in the brain regions associated with reward, such as the orbitofrontal cortex, striatum, anterior cingulate gyrus, precuneus and the ventral tegmental area.

“We found that this disruption of the reward system correlates with the number of problems, such as family issues, individuals have because of their marijuana use,” Filbey said. “Continued marijuana use despite these problems is an indicator of .”

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Richard Lowe

Richard Lowe is a 14-year veteran of the financial sector with licenses as a commodity broker (Series 3) and investment advisor representative (IAR Series 65). Along with a focus on raising capital for the firms he was employed with, he also wrote and edited much of the content published by them. He holds a BA in Journalism from the University of Massachusetts. He has been a longtime advocate for marijuana legalization due to the social injustices associated with marijuana prohibition and the strong potential for the medicinal benefits of cannabis.

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  1. Study finds insulin has this same effect, especially when family members oppose the use of this life saving drug.

    I guess I should read the study before criticizing it, but the article sure does not explain why people were using the drug and if they thought it helped them. If something helps you, but it is illegal, that can mess with your head.

  2. I should have a reward anticipation response looking at good bud. Also looking at a pretty girl, a great meal and any pleasurable thing I see you would think. Whether that is bad or not is questionable.

  3. You have to look at it like this. Everyone is different as far as body chemestry, etc. I’ve been using marijuana for 43 years. There is no such thing as marijuana dependence. You don’t have sick withdrawals like you would with cocaine, alcohol, heroin, etc and it is a schedule 1. If anything alcohol should be schedule 1.

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