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CBD Counters Effects of THC Study Shows

There are Many Active Compounds in Marijuana and they all Work Together in Interesting Ways

Research is still ongoing and will be for a long time on marijuana, but some research is showing very interesting results. THC is the active compound that causes the euphoric effects of cannabis, and it has shown some adverse effects on memory, but research is also showing that CBD counters the effects of THC. In other words, strains of marijuana with an approximate equal amount of CBD and THC can cause a balanced effect where the CBD counters the THC.

Marijuana with relatively high levels of a compound called cannabidiol may be less risky to smoke over the long term, because this ingredient may counteract some of the drug’s harmful effects, according to a new study in mice.

The study found that adolescent mice injected with frequent doses of tetrahydrocannabinol (THC) — the ingredient in marijuana that produces a “high” — showed signs of impaired memory and increased anxiety over the long term. But mice that received daily doses of THC combined with an equal amount of cannabidiol (CBD) did not experience these negative effects.

The study “suggests that strains of cannabis with similar levels of CBD and THC would pose significantly less long-term risk due to CBD’s protective effect against THC,” study author Dr. Ken Mackie, a professor in the Department of Psychological and Brain Sciences at Indiana University, said in a statement.

Over the last several decades, THC levels in marijuana used in the United States have increased 300 percent, while levels of CBD in marijuana have decreased, the researchers said. But the long-term effects of exposure to THC and CBD need to be studied further, they said. [25 Odd Facts About Marijuana]

Studies on whether CBD can counteract the negative effects of THC have been mixed, according to a 2013 review paper on the topic. For example, some studies have found that people experience fewer symptoms of anxiety when they smoke marijuana with high CBD levels, compared to when they smoke marijuana with high THC levels, but other studies failed to replicate these results, according to the review. Another study, published in 2011, found that people who tended to use marijuana products with high CBD levels were at lower risk for psychotic symptoms over the long term, although the effect was subtle.

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